3D-micro-MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with reference to their pharmacokinetic properties
نویسندگان
چکیده
منابع مشابه
3D-Rotational Phase-Contrast MR Angiography
Introduction For many applications of MRI angiography (MRA), high spatial resolution images obtained in reasonable scan times are required. For significantly decreasing the image acquisition time, projection reconstruction based approaches have been proposed, using highly undersampled two-dimensional projections [1,2]. These methods have e.g. been successfully applied to temporally resolved MRA...
متن کاملTime-resolved contrast-enhanced 3D MR angiography.
An MR angiographic technique, referred to as 3D TRICKS (3D time-resolved imaging of contrast kinetics) has been developed. This technique combines and extends to 3D imaging several previously published elements. These elements include an increased sampling rate for lower spatial frequencies, temporal interpolation of k-space views, and zero-filling in the slice-encoding dimension. When appropri...
متن کاملNovel intravascular macromolecular MRI contrast agent with generation-4 polyamidoamine dendrimer core: accelerated renal excretion with coinjection of lysine.
One of the major limitations to macromolecular MRI contrast agents (MRI-CAs) is their slow clearance and associated decreased excretion of gadolinium (Gd(III)). The effect of coinjecting lysine to accelerate renal excretion of a macromolecular MRI-CA (generation-4 PAMAM dendrimer (G4D-(1B4M-Gd)64)) was investigated. The biodistribution and urine and fecal excretion in athymic mice was evaluated...
متن کاملMicro-MR Angiography Using Gd-Loaded Micelles As Intravascular Contrast Agents In Mouse Models Amyloid Angiopathy
L. K. Hill, K. C. Briley-Saebo, M. Douadi, A. Baig, S. Pun, B. J. Nieman, D. H. Turnbull, Z. A. Fayad, T. Wisniewski, and Y. Z. Wadghiri Radiology, NYU School of Medicine, New York, NY, United States, Radiology, Mount Sinai School of Medicine, New York, NY, United States, Skirball Institute of Biomolecular Medicine, NYU School of Medicine, New York, NY, United States, Pathology&Neurology&Psychi...
متن کاملMR Lymphangiography Using Nano-Sized Paramagnetic Contrast Agents with Dendrimer Cores
Imaging of the lymphatic system is difficult because its channels and lymph nodes are small and not directly accessible. Currently, two clinical methods, the direct lymphangiography and the lymphoscintigraphy, are used to visualize parts of the human lymphatic system, but have significant limitations. Nano-sized contrast agents have recently been evaluated to be advantageous for visualization o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2001
ISSN: 0740-3194,1522-2594
DOI: 10.1002/1522-2594(200103)45:3<454::aid-mrm1060>3.0.co;2-m